|
KMID : 0370220070510040246
|
|
Yakhak Hoeji
2007 Volume.51 No. 4 p.246 ~ p.252
|
|
|
Synthesis of Urea and Thiourea Derivatives and Their Inhibitory Activities of NO Production by Activated Macrophages
|
|
Kim Yoon-Jung
Cheon Ye-Jin
Lim Hyo-Jin
Ryu Jae-Ha
Jeon Ra-Ok
|
|
|
Abstract
|
|
|
|
Several ureas and thioureas were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Among these compounds, indole-containing thiourea 6e was the most potent showing 17.4 ${\mu}M$ of $IC_{50}$ value
|
|
|
KEYWORD
|
|
|
urea, thiourea, nitric oxide, iNOS, indole, benzoxazole
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|